Antitumor activity of the novel pyridine derivative
نویسندگان
چکیده
Introduction: The study aim was to explore a toxicological property and antitumor action of the novel pyridine derivative LHT-17-19 in cell culture on experimental models lung cancer mice.
 Materials methods: performed male female ICR(CD-1), BALB/c, BALB/c nu/nu mice. Pyridine derivative (LHT-17-19) studied as water-soluble pharmaceutical substance. Acute toxicity evaluated groups 5 animals, results were analyzed by Finney. Antitumor antimetastatic activity syngeneic xenograft Results discussion: belongs class 3 classification chemicals accordance with GOST 12.1.007–76. substance demonstrated an mice tumor Lewis carcinoma well heterotopic model non-small humanized animals.
 Conclusion: WHO recommendation. exerts both patient-derived murine models.
 Graphical abstract:
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ژورنال
عنوان ژورنال: Research results in pharmacology
سال: 2022
ISSN: ['2658-381X']
DOI: https://doi.org/10.3897/rrpharmacology.8.89997